Clinical confocal microlaparoscope for real-time in vivo optical biopsies

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This publication represented 1 of 3 journal articles that comprimised my dissertation. This paper discusses the design of the confocal microlaparoscope. Full details are in the Paper.

Citation: Anthony A Tanbakuchi, Andrew R Rouse, Joshua A Udovich, Kenneth D Hatch, and Arthur F Gmitro. Clinical confocal microlaparoscope for real-time in vivo optical biopsies. J Biomed Opt, 14(4):044030, 2009. PDF

Monte Carlo characterization of parallelized fluorescence confocal systems imaging in turbid media

This publication represented 1 of 3 journal articles that comprimised my dissertation. For this paper I developed and coded a Monte Carlo model to simulate a confocal system imaging in tissue to model performance characteristics of the system. The results showed that a new type of confocal design, a multi-point scanner, would significantly improve the current design. This resulted in a new system, as well as a a patent application.

Citation: Anthony A Tanbakuchi, Andrew R Rouse, and Arthur F Gmitro. Monte carlo characterization of parallelized fluorescence confocal systems imaging in turbid media. J Biomed Opt, 14(4):044024, 2009 PDF

Dissertation complete!

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After many years of hard work, I completed my PhD in Optical Sciences at the University of Arizona. You can read my dissertation which focused on the development of a novel confocal microlaparoscope for surgical use. I was lucky enough to have a project where I could design, develop, and test a new optical instrument in human clinical trials. It was hard work, an exceptional opportunity, and a great experience.

This work would not have been possible without the collaborative efforts of Dr. Arthur Gmitro, Dr. Andrew Rouse, Dr. Molly Brewer, Dr. Kenneth Hatch, and Dr. Richard Sampliner. All of these individuals contributed insight and expertise that made this project a success. Dr. Gmitro provided the initial vision and direction for in vivo confocal imaging systems and obtained the funding to support the work. Dr. Rouse had significant participation in the project and provided important guidance. Dr. Brewer helped motivate the development of the instrument and gave guidance on how such an instrument would be used in a clinical setting. Dr. Hatch served as the primary clinician to test the device in vivo. Dr. Sampliner provided human esophagus biopsies for the ex vivo imaging studies. I would also like to thank Kathy Schmidt and the surgical staff at umc who provided critical assistance during the clinical trials and Dr. Katerina Dvorak and Angelique Kano for providing mice to image with the bare fiber probes.

Funding for this work was provided by the Arizona Disease Control Research Commission grant number 971, nih grants ca 94287 and ca 115780, the BMIS Fellowship, and the Imaging Fellowship.

I would like to thank my dissertation committee, Dr. Arthur Gmitro, Dr. Andrew Rouse, Dr. Urs Utzinger, and Dr. Jim Schwiegerling, for providing guidance and constructive criticism.

Finally, I would never have accomplished this work without the inspiration I received from the handful of great teachers. I feel lucky to have been their student. I hope that I will be able to give back to society as much as they gave to their students. Thank you Dr. Russell Kraus, Priscilla Morton, Fred Marinello, and Robert Petitmermet.

Citation: Anthony A Tanbakuchi. A surgical confocal microlaparoscope for real-time optical biopsies, University of Arizona, Tucson, Az, 2009. PDF

Method and apparatus for adaptive pixel correction of multi-color matrix patent

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This is a patent that resulted from my work at Philips Research Labs in Endhoven, The Netherlands. I was working in the Image Sensors division (later sold to DALSA) when I developed this pixel defect correction algorithm. You can read the full patent.

Citation: A. Tanbakuchi, "Method and apparatus for adaptive pixel correction of multi-color matrix," US 7477781 B1, Jan 13, 2009. PDF.